TBK (pSer172) anticorps

N° du produit ABIN390010

Cet anticorps Lapin Polyclonal détecte spécifiquement dans DB. Il présente une réactivité envers Humain et a été mentionné dans 1 publication.

Aperçu rapide pour TBK (pSer172) anticorps (ABIN390010)

Antigène: TBK

Reactivité: Humain

Hôte: Lapin

Clonalité: Polyclonal

Conjugué: Inconjugué

Application: Dot Blot (DB)

Clone: RB16573

Détail du produit

Épitope: pSer172

Homologie: Zf, M, X

Purification: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogène: This TBK Antibody is generated from rabbits immunized with a KLH conjugated synthetic phosphopeptide corresponding to amino acid residues surrounding S172 of human TBK.

Isotype: Ig Fraction

Information d'application

Indications d'application: DB: 1:500

Restrictions: For Research Use only

Stockage

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Agent conservateur: Sodium azide

Précaution d'utilisation: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Stock: 4 °C,-20 °C

Stockage commentaire: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Date de péremption: 6 months

Référence

Muvaffak, Pan, Yan, Fernandez, Lim, Dolinski, Nguyen, Strack, Wu, Chung, Zhang, Hulton, Ripley, Hirsch, Nagashima, Wong, Jánne, Seidel-Dugan, Zawel, Kirschmeier, Middleton, Morris, Wang: "Evaluating TBK1 as a therapeutic target in cancers with activated IRF3." dans: Molecular cancer research : MCR, Vol. 12, Issue 7, pp. 1055-66, (2014) (PubMed).

Détail du antigène

Antigène: TBK

Sujet: The NF-kappa-B (NFKB) complex of proteins is inhibited by I-kappa-B (IKB) proteins, which inactivate NFKB by trapping it in the cytoplasm. Phosphorylation of serine residues on the IKB proteins by IKB kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation and nuclear translocation of the NFKB complex. TKB is similar to IKB kinases and can mediate NFKB activation in response to certain growth factors. The protein can form a complex with the IKB protein TANK and TRAF2 and release the NFKB inhibition caused by TANK.

Poids moléculaire: 83642

ID gène: 29110

NCBI Accession: NP_037386

UniProt: Q9UHD2